The coronavirus disease (otherwise known as Covid-19) has become a buzzword worldwide. Its significant death toll and damning social, cultural, political, and economic impact have halted the whole world within a brief timeframe. In its wake, it has caused hunger, famine, health hazards, disruption in academic calendars, and deaths in most countries worldwide. Policymakers’ responses to curtailing this pandemic’s impact have been subject to their institutional, infrastructural, and human capacities. In Nigeria, as in other countries, the state of preparedness in curtailing the spread of the virus and its impact on the socio-political and economic domains are under scrutiny. This paper uses reports and representations to assess Nigeria’s socio-political and economic responses in its fight against Covid-19 amidst other internal challenges such as unemployment, hunger, and corruption. The paper examines the degree of vulnerability of different sectors of the Nigerian socio-political and economic spaces in terms of human resources and capacity, political and economic configuration, and the effectiveness of the government’s policy responses. The Covid-19 pandemic further unmasks the deteriorated state of the Nigerian socio-political and economic spheres and deepens the woes and challenges of the nation.