Anti-oppressive practice (AOP) has emerged, particularly within the British Commonwealth countries, as one of the primary approaches to realizing social work’s historic commitment to social justice. Despite the promise of AOP to advance the profession’s capacity to advocate on behalf of societies’ most vulnerable groups, it poses a serious challenge to social workers who hold orthodox religious beliefs, including Christians. This paper describes the key principles of AOP, assesses its strengths and weaknesses, and shows what aspects of AOP are incompatible with a Christian worldview and what aspects are compatible with and can be embraced by Christian social work educators.